CNA (LMI 1195)
A PET agent designed to identify patients at risk of sudden cardiac death
LMI 1195 is a fluorine 18-based photon emission tomography (PET) agent designed for cardiac neuronal imaging. As a novel F 18 small molecule tracer, LMI 1195 may help better identify patients at risk of sudden cardiac death (SCD) and fatal arrhythmias. These patients might benefit from interventional therapy, such as an implantable cardioverter defibrillator (ICD), in order to decrease risk of SCD.
Preliminary Phase 1 study results show that LMI 1195 has favorable safety, dosimetry and tolerability profiles.
In addition, LMI 1195 provided high-quality, well-defined three-dimensional images of the autonomic nervous system of the heart. The initial data also showed that myocardial uptake of LMI 1195 was high and uniform throughout the heart and the radiotracer cleared quickly from the blood.