Products

QUADRAMET®

QuadrametQUADRAMET® is an injectable radiopharmaceutical used to treat bone pain associated with certain kinds of cancer.

It is primarily used to treat the pain associated with osteoblastic bone metastases confirmed on a radionuclide bone scan and has demonstrated efficacy in patients with prostate, breast and other primary cancers.1,2,3

QUADRAMET® may manage cancer bone pain with relief as early as one week.1,2

Questions?

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Important Safety Information

INDICATIONS AND USAGE

QUADRAMET® is indicated for relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan.

SELECTED IMPORTANT RISK INFORMATION

Contraindications:

QUADRAMET® is contraindicated in patients who have known hypersensitivity to EDTMP or similar phosphonate compounds.

Warnings and precautions:
QUADRAMET® causes bone marrow suppression. Before administered, the patient’s current clinical, hematological status, and bone marrow response history to myelotoxic agents should be considered. Metastatic prostate and other cancers can be associated with disseminated intravascular coagulation (DIC); caution should be exercised in treating cancer patients whose platelet counts are falling or who have other findings suggesting DIC. Blood counts should be monitored weekly for at least 8 weeks or until bone marrow recovery.

The potential for additive bone marrow toxicity of QUADRAMET® with chemotherapy or external beam radiation has not been studied. QUADRAMET® should not be administered concurrently with either of these treatments unless the benefits outweigh the risks and adequate marrow recovery has occurred.

QUADRAMET® can cause fetal harm. Women of childbearing potential should be advised to avoid becoming pregnant soon after receiving QUADRAMET®. If administered, pregnant patients should be apprised of the potential hazard to the fetus and the potential for serious adverse reactions in nursing infants.

Adverse reactions:
The most frequent events are leukopenia, thrombocytopenia, and spinal cord compression in patients with cervical, thoracic, or lumbar spine metastases.

Please see full Prescribing Information.

Ordering Information

Customer Service: 1-800-299-3431
Online: https://ecommerce.lantheus.com
Fax Orders/POs: 1-978-436-7501
Email: mics@lantheus.com

Catalog Number Product Description
SM3-W QUADRAMET® SM-153 EDTMP 5550MBq
V9 QUADRAMET® Vial Shield

References:

  1. Sartor O. et al., Samarium-153-Lexidronam Complex Treatment of Painful bone Metastases In Hormone-Refractory Prostate Cancer, UROLOGY, 2004;63:940-945.
  2. Quadramet® [Package Insert]. N. Billerica, MA: Lantheus Medical Imaging,Inc: 2014.
  3. Morris M. et al., Phase I Study of Samarium-153 Lexidronam With docetaxel in Castration-Resistant Metastatic Prostate Cancer, Journal of Clinical Oncology, 2009;27:2436-2442.