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Thallium-201

Thallium

Thallium-201 is a radiopharmaceutical used in myocardial perfusion imaging (MPI) using either planar or single photon emission computed tomography (SPECT) techniques for the diagnosis and localization of myocardial infarction.

Thallium-201 may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect.

Additionally, Thallium-201 may be used in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease) and is also indicated for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels.

Lantheus was the first to commercially launch Thallium in 1977.

Thallium Clinical Image

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Important Safety Information

INDICATIONS AND USAGE

Thallous Chloride Tl 201 Injection may be useful in myocardial perfusion imaging using either planar or SPECT (Single Photon Computed Tomography) techniques for the diagnosis and localization of myocardial infarction.  It may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect.

Thallous Chloride Tl 201 Injection may also be useful in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease).

It is usually not possible to differentiate recent from old myocardial infarction, or to differentiate between recent myocardial infarction and ischemia.

Thallous Chloride Tl 201 is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels.  It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination.  Thallous Chloride Tl 201 Injection has not been adequately demonstrated to be effective for the localization of normal parathyroid glands.

CONTRAINDICATIONS

None known.

Important Safety Information

Following the administration of Thallous Chloride Tl 201 Injection, adverse anaphylactoid reactions have been reported (characterized by cardiovascular, respiratory, and cutaneous symptoms), some severe enough to require treatment.  Hypotension, pruritus, flushing and diffuse rash which responds to antihistamines have been reported.  Other reported events include itching, nausea/vomiting, mild diarrhea, tremor, shortness of breath, chills, fever, conjunctivitis, sweating and blurred vision.

WARNINGS

In studying patients in whom myocardial infarction or ischemia is known or suspected, care should be taken to assure continuous clinical monitoring and treatment in accordance with safe, accepted procedure.  Exercise stress testing should be performed only under the supervision of a qualified physician and in a laboratory equipped with appropriate resuscitation equipment.

The vial stopper contains dry natural rubber latex and may cause allergic reactions in providers or patients who are sensitive to latex.

PRECAUTIONS

Data are not available concerning the effect of marked alterations in blood glucose, insulin, or pH (such as is found in diabetes mellitus) on the quality of Thallous ­Chloride Tl 201 Injection scans.  Attention is directed to the fact that thallium is a potassium analog, and since the transport of potassium is affected by these factors, the possibility exists that the thallium may likewise be affected.

General
The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.

Thallous Chloride Tl 201 Injection, as all radioactive materials, must be handled with care and used with appropriate safety measures to minimize external radiation exposure to patients and to clinical personnel.

Radiopharmaceuticals should be used only by physicians who are qualified by training and experience in the safe use and handling of radionuclides.

Please see full Prescribing Information.

Ordering Information

Customer Service: 1-800-299-3431
Online: https://ecommerce.lantheus.com
Fax Orders/POs: 1-978-436-7501
Email: mics@lantheus.com

Catalog Number mCi* MBq
T6 6.6 244.2
T8 8.8 325.6
T10 11 407
T18 19.8 732.6

*mCi at day of calibration

  1. Refer to the chart below to convert into mCi’s.
  2. For each mCi needed at administration time, multiply by the factor shown in your time zone.
  3. Total your mCi’s for all administrations and round to the nearest whole mCi.
  4. Call your Lantheus Medical Imaging Customer Service Representative and place your order in mCi (7 mCi minimum order).
Local Administrative Time Local Time mCi Conversion
 EST CST MST PST
 02:00 AM 0.945  0.954  0.963  0.972
 03:00 AM  0.954 0.963  0.972  0.981
 04:00 AM  0.963 0.972  0.981  0.991
05:00 AM  0.972  0.981  0.991 1.000
06:00 AM  0.981  0.991  1.000 1.010
07:00 AM  0.991  1.000  1.010  1.019
08:00 AM  1.000  1.010 1.019  1.029
09:00 AM  1.010  1.019  1.029  1.039
10:00 AM 1.019 1.029 1.039 1.049
11:00 AM 1.029 1.039 1.049 1.059
12:00 PM 1.039 1.049 1.059 1.069
01:00 PM 1.049 1.059 1.069 1.079
02:00 PM 1.059 1.069 1.079 1.089
03:00 PM 1.069 1.079 1.089 1.100
04:00 PM 1.079 1.089 1.100 1.110
05:00 PM 1.089 1.100 1.110 1.121
06:00 PM 1.100 1.110 1.121 1.132
07:00 PM 1.110 1.121 1.132 1.142
08:00 PM 1.121 1.132 1.142 1.153