Pipeline
As we think about the future of medicine, we’re exploring new frontiers across a diverse and robust range of product candidates and disease states. All with the vision of developing game-changing solutions for patients.
Diagnostic
Prostate cancer
| Candidate | Target | Isotope | Indication/Disease Area | Pre-Clin. | Phase 1 | Phase 2 | Phase 3 | Reg. Filing |
|---|---|---|---|---|---|---|---|---|
| LNTH-24011 | Target: GRPR | Isotope: 68Ga |
Indication/Disease Area: Metastatic prostate cancer |
Phase: Phase 2
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LNTH-2401 is a novel radiodiagnostic targeting the gastrin-releasing peptide receptor. |
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Neuroendocrine tumors
| Candidate | Target | Isotope | Indication/Disease Area | Pre-Clin. | Phase 1 | Phase 2 | Phase 3 | Reg. Filing |
|---|---|---|---|---|---|---|---|---|
| LNTH-2501/EVG-001 | Target: SSTR2 | Isotope: 68Ga |
Indication/Disease Area: Neuroendocrine tumors |
Phase: Reg. Filing
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LNTH-2501/EVG-001 is a diagnostic kit for the preparation of Ga-68 edotreotide Injection, indicated for use with PET imaging for the localization of somatostatin receptor-positive (SSTR+) neuroendocrine tumors (NETs) in adult and pediatric patients. |
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Other solid tumors
| Candidate | Target | Isotope | Indication/Disease Area | Pre-Clin. | Phase 1 | Phase 2 | Phase 3 | Reg. Filing |
|---|---|---|---|---|---|---|---|---|
| LNTH-1363S* | Target: FAP | Isotope: 64Cu |
Indication/Disease Area: Tumor/fibrosis assessment |
Phase: Phase 1
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LNTH-1363S is a fibroblast activation protein, copper-64 labeled radiodiagnostic with broad potential imaging applicability and use in oncology. Learn more about our clinical trial. |
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| LNTH-2503 | Target: CCK2R | Isotope: 68Ga |
Indication/Disease Area: Small cell lung cancer |
Phase: Phase 1
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LNTH-2503 is a highly specific peptide vector radiodiagnostic, which binds to the cholecystokinin-2 receptor (CCK2), a highly expressed tumor marker in cancers like small cell lung cancer (SCLC). |
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| LNTH-2505 | Target: Undisc. | Isotope: 68Ga |
Indication/Disease Area: Glioblastoma |
Phase: Preclinical
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LNTH-2505 is a molecularly targeted tracer that binds to a glial cell surface molecule which may be used for the diagnosis of glioblastoma (GBM) and potentially other glial tumors. |
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| LNTH-2507 | Target: Undisc. | Isotope: 68Ga |
Indication/Disease Area: Pancreatic ductal adenocarcinoma |
Phase: Preclinical
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LNTH-2507 is a radiodiagnostic tracer targeting a cell surface molecule for the treatment of pancreatic ductal adenocarcinoma (PDAC). |
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| LNTH-2509 | Target: Undisc. | Isotope: 68Ga |
Indication/Disease Area: Lobular breast cancer |
Phase: Preclinical
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LNTH-2509 is a radiodiagnostic tracer targeting a cell surface molecule for the treatment of lobular breast cancer. |
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Neurology/other
| Candidate | Target | Isotope | Indication/Disease Area | Pre-Clin. | Phase 1 | Phase 2 | Phase 3 | Reg. Filing |
|---|---|---|---|---|---|---|---|---|
| MK-6240* (florquinitau) | Target: Tau | Isotope: 18F |
Indication/Disease Area: Alzheimer’s disease |
Phase: Reg. Filing
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Florquinitau is a next-generation tau-targeting radiodiagnostic for Alzheimer’s disease. |
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| NAV-4694* (flutafuranol) | Target: ß amyloid | Isotope: 18F |
Indication/Disease Area: Alzheimer’s disease |
Phase: Phase 3
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| LNTH-2515 (florbetaben) | Target: Amyloid | Isotope: 18F |
Indication/Disease Area: Cardiac AL amyloidosis |
Phase: Phase 3
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LNTH-2515 (florbetaben) is an F-18 labeled radiodiagnostic stilbene derivative that binds to amyloid deposits and is being studied in patients with cardiac amyloidosis. The FDA has granted Fast Track designation for the development of LNTH-2515 (florbetaben) imaging for the diagnosis of AL (amyloid light chain) and ATTR (transthyretin amyloid cardiomyopathy) cardiac amyloidosis. Learn more about our clinical trial. |
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| LNTH-2620/PI-2620 | Target: Tau | Isotope: 18F |
Indication/Disease Area: Alzheimer’s disease |
Phase: Phase 3
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LNTH-2620/PI-2620 is an F-18 labeled small molecule specifically targeting tau used as a radiodiagnostic in conjunction with PET imaging to show aggregated tau protein in people with Alzheimer’s disease and other tauopathies. It binds to both isoforms of tau (4R and 3R/4R repeats). The FDA has granted Fast Track designation for the development of LNTH-2620/PI-2620 in Alzheimer’s disease (AD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Learn more about our clinical trial. |
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| LNTH-2511 (DED) | Target: MAO-B | Isotope: 18F |
Indication/Disease Area: Neuroinflammation |
Phase: Phase 1
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LNTH-2511 (DED) is an F-18 labeled small molecule specifically targeting reactive astrocytes during neuroinflammation, which presents in diseases such as Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS) and Parkinson’s disease. |
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| LNTH-2513 (GP1) | Target: GPIIb-IIIa | Isotope: 18F |
Indication/Disease Area: Thromboembolism |
Phase: Phase 2
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LNTH-2513 (GP1) is a small F-18 labeled molecule, specifically designed to image active thrombi (new blood clots) by binding to activated GPllb/llla receptors, which are involved in thrombus formation and propagation. LNTH-2513 (GP1) is the first PET tracer shown to be able to detect acute thromboembolic events in humans. |
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Therapeutic
Prostate cancer
| Candidate | Target | Isotope | Indication/Disease Area | Pre-Clin. | Phase 1 | Phase 2 | Phase 3 | Reg. Filing |
|---|---|---|---|---|---|---|---|---|
| LNTH-24022 | Target: GRPR | Isotope: 177Lu |
Indication/Disease Area: Metastatic prostate cancer |
Phase: Preclinical
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LNTH-2402 is a novel gastrin-releasing peptide receptor targeted radiotherapeutic for solid tumors including prostate, breast, lung and other cancers. |
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Other solid tumors
| Candidate | Target | Isotope | Indication/Disease Area | Pre-Clin. | Phase 1 | Phase 2 | Phase 3 | Reg. Filing |
|---|---|---|---|---|---|---|---|---|
| LNTH-2403 | Target: LRRC15 | Isotope: 177Lu |
Indication/Disease Area: Osteosarcoma |
Phase: Phase 1
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LNTH-2403 is a leucine-rich repeat-containing protein 15 targeted radiotherapeutic. It received Orphan Drug and Rare Pediatric Disease designations from the U.S. FDA for the treatment of osteosarcoma. Learn more about our clinical trial. |
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| LNTH-2404 | Target: TROP2 | Isotope: Undisc. |
Indication/Disease Area: Solid tumors |
Phase: Preclinical
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LNTH-2404 is a trophoblast cell surface antigen-2 targeted radiotherapeutic. |
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| LNTH-2503 | Target: CCK2R | Isotope: 177Lu |
Indication/Disease Area: Small cell lung cancer |
Phase: Phase 1
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LNTH-2503 is a highly specific peptide vector radiotherapeutic, which binds to the cholecystokinin-2 receptor (CCK2), a highly expressed tumor marker in cancers like small cell lung cancer (SCLC). |
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| LNTH-2505 | Target: Undisc. | Isotope: 177Lu |
Indication/Disease Area: Glioblastoma |
Phase: Preclinical
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LNTH-2505 is a molecularly targeted tracer that binds to a glial cell surface molecule which may be used for the treatment of glioblastoma (GBM) and potentially other glial tumors. |
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| LNTH-2507 | Target: Undisc. | Isotope: 177Lu |
Indication/Disease Area: Pancreatic ductal adenocarcinoma |
Phase: Preclinical
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LNTH-2507 is a radiotherapeutic targeting a cell surface molecule for the treatment of pancreatic ductal adenocarcinoma (PDAC). |
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| LNTH-2509 | Target: Undisc. | Isotope: 177Lu |
Indication/Disease Area: Lobular breast cancer |
Phase: Preclinical
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LNTH-2509 is a radiotherapeutic targeting a cell surface molecule for the treatment of lobular breast cancer. |
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Each of these product candidates is an investigational drug that has not yet been approved as safe and effective.
GRPR, Gastrin-releasing peptide receptor; SSTR2, Somatostatin receptor type 2; FAP, Fibroblast activation protein; CCK2R, Cholecystokinin-2 receptor; MAO-B, Monoamine oxidase-B; GPIIb-IIIa, Glycoprotein IIb-IIIa; LRRC15, Leucine-rich repeat-containing protein 15; TROP2, Trophoblast cell surface antigen-2.
1. Also known as 68Ga-RM2. 2. Also known as 177Lu-RM2.
*We are actively partnering with researchers on these assets to provide appropriate biomarkers in relevant studies. If interested, please contact biomarkers@lantheus.com for more information.
